說明:

  1. 由於肺癌是全世界發病率最高,並且死亡率最高的癌症,急需有降低其對人們健康衝擊的解決方案。
  2. 越來越多的證據表明,身體活動可降低患肺癌的風險。
  3. 大多數研究支持的事實是,總和性以及娛樂性的身體活動可降低女性20-30%肺癌風險,對男性可降低20-50%肺癌風險,且有劑量反應效果(dose-response effect)的證據(: 身體活動愈多,愈能減少肺癌的發生)
  4. 身體活動和肺癌之間操作所述生物機制可能複雜並且由許多因素,包括遺傳性或獲得易感基因,性別,吸煙和其他環境因素的影響。
  5. 幾個假設性合理的生物因素和機制說明身體活動為何可減少肺癌的風險,包括:改善肺功能,減少了肺中致癌物質濃度,增強免疫功能,減少發炎,增強DNA修復能力,改變生長因子濃度和可能的基因身體活動的相互作用。
  6. 未來的研究應針對可能的亞組的影響和可能涉及的生物學機制進一步探討。

評論:

  1. 依據國民健康署公布的資料顯示民國101年,肺癌發生率在十大癌症中排名第二,僅次於大腸癌,肺癌增加人數主要為女性。肺癌對國人健康的威脅不可忽視。(http://www.nownews.com/n/2015/04/14/1667623)
  2. 雖然過去的研究一直強調運動可預防癌症,但此篇研究給大家的正向訊息是除了運動,日常的活動對降低肺癌的發生也有貢獻度。
  3. 現代人尤其是上班族,大多久坐於會議桌或電腦前,為了自己的健康,請多活動,所謂『活動』的意義就是要『活』就要『動』

2015-10-6

參考文獻:

Recent Results Cancer Res. 2011;186:101-33. doi: 10.1007/978-3-642-04231-7_5.

Physical activity and lung cancer prevention.

Emaus A1, Thune I.

Author information

  • 1Division of Cancer Etiology, Department of Population Science, City of Hope National Medical Center, Duarte, CA, USA. aina.emaus@medisin.uio.no

Abstract

Since lung cancer is among the cancers with the highest incidence and has the highest mortality rate of cancer worldwide, the means of reducing its impact are urgently needed. Emerging evidence shows that physical activity plays an etiological role in lung cancer risk reduction. The majority of studies support the fact that total and recreational physical activity reduces lung cancer risk by 20-30% for women and 20-50% for men, and there is evidence of a dose-response effect. The biological mechanisms operating between physical activity and lung cancer are likely complex and influenced by many factors including inherited or acquired susceptibility genes, gender, smoking, and other environmental factors. Several plausible biological factors and mechanisms have been hypothesized linking physical activity to reduced lung cancer risk including: improved pulmonary function, reduced concentrations of carcinogenic agents in the lungs, enhanced immune function, reduced inflammation, enhanced DNA repair capacity, changes in growth factor levels and possible gene-physical activity interactions. Future research should target the possible subgroup effects and the biologic mechanisms that may be involved.

PMID:

21113762

[PubMed – indexed for MEDLINE]

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